INDIANAPOLIS - Both the offense and the defense provided some big plays as the Colts edged out their division rivals in Jim Caldwell's debut as head coach.

Peyton Manning's passing game was in sync, as he completed 28 of 38 passes for 301 yards and a touchdown to Reggie Wayne. Wayne caught 10 passes for 162 yards - his sixth game of 100 or more yards against the Jaguars. However, the Colts failed to convert a one-yard run on third and fourth down with two minutes left that could have iced the game.

Jacksonville took over at its own 35, and the Colts defense smothered Jaguars quarterback David Garrard on three straight plays to keep them from reaching a potential game-tying field goal.

MIAMI - The Colts offense had the ball for less than 15 minutes in one of the most stunning wins in Monday Night Football history.

Indianapolis trailed four times in the game, and the defense had trouble with Miami's running game and “wildcat” offense. The Dolphins rushed for 239 yards and converted 15 of 21 third-down plays.

Despite the defensive troubles, Manning would not be denied. On the game-winning drive, Manning moved the Colts 80 yards in 32 seconds. He read the blitz and hit Pierre Garcon on a slant pass, which Garcon turned into a 48-yard touchdown.

Manning finished with 14-of-23 passing for 303 yards and two touchdowns. Dallas Clark, who scored on an 80-yard pass play from the first play of scrimmage, had seven catches for 183 yards. The Colts set an NFL record for winning with the smallest time of possession (14:53).

PHOENIX - Manning threw for 379 yards and four touchdowns as the Colts cruised to a big win over the defending NFC champion Arizona Cardinals.

Manning threw three touchdown passes in the second quarter - 20 yards to Wayne, 10 yards to Clark and 53 yards to Garcon - to put the Colts in firm control. The running game also contributed, as Joseph Addai (63 yards) and Donald Brown (40 yards) combined to break 100 yards.

Indy's defense put major pressure on Cardinals quarterback Kurt Warner, sacking him four times and intercepting two passes. Warner threw for 332 yards, but only one score. The Colts held Arizona to 24 yards rushing.

INDIANAPOLIS - The Colts led from start to finish in another strong offensive display.

Manning threw for 353 yards and two touchdowns, setting a team record with his fourth consecutive game of 300 or more yards passing. Four Colts scored touchdowns (Brown on a one-yard run, Wayne on a five-yard pass, Austin Collie on a 21-yard pass and Addai on a 12-yard run) and four had at least 65 yards receiving (Clark 80, Wayne 74, Garcon 71 and Collie 65).

The defense held the Seahawks to 49 yards rushing and sacked Seneca Wallace five times. Robert Mathis had 2.5 sacks and forced two fumbles.

NASHVILLE - Manning turned in his fifth straight 300-yard passing game, one shy of the NFL record, and the Colts set a franchise mark with their 14th consecutive regular-season win. Manning completed 36 of 44 passes for 309 yards, connecting on two scoring passes to Collie and one to Wayne. The Colts defense, meanwhile, limited the Titans to three field goals and 90 yards rushing.

The highlight drive of the game came late in the second quarter when Manning moved the Colts 93 yards in 47 seconds, capped by a 39-yard catch-and-elude-defenders play by Collie. Collie finished with eight catches for 97 yards.

ST. LOUIS - The Colts flourished in all aspects in a game against the winless St. Louis Rams that was as one-sided as expected.

Manning completed 23 of 34 passes for 235 yards - snapping his streak of 300-yard games - and three touchdowns. The first drive of the game set the tone, as the Colts marched 90 yards with Manning hitting Wayne four times (14, 25, 16 and 6 yards) with the final connection a touchdown. Manning also threw touchdown passes to Collie and Clark. Joseph Addai added 64 yards rushing and a touchdown, and Donald Brown rushed for 58 yards.

The Colts defense recorded three sacks and two takeaways, with rookie cornerback Jacob Lacey returning an interception 35 yards for a score.

INDIANAPOLIS - Facing a tight situation and the possibility of their first loss, the Colts pulled out a trick play: Joseph Addai threw a 22-yard halfback pass touchdown to Reggie Wayne on the first play of the fourth quarter to give the Colts the win.

Wayne, bothered by a groin injury earlier in the week, caught a career-high 12 passes for 147 yards and that one score. Manning completed 31 of 48 passes for 347 yards on a day when the offense didn't seem to be entirely in sync. Field goal kicker Matt Stover, playing in his second game after taking over for injured Adam Vinatieri, hit field goals of 38, 33, 31 and 40 yards.

Manning became the fourth quarterback to reach 4,000 career completions, joining Brett Favre, Dan Marino and John Elway in the elite club.

The Colts stopped the 49ers' last two drives with sacks by Mathis and Dwight Freeney. Freeney tied Mathis' record with his eighth consecutive game of at least one sack.

INDIANAPOLIS - Manning staged his 39th career fourth-quarter game-winning drive, directing the Colts 61 yards on eight plays, hitting key passes to Clark and Collie along the way.

Joseph Addai powered over for the game-winning touchdown on one of his best games of the season (63 yards rushing, 49 yards receiving and two touchdowns). Clark recorded a career-high 14 catches for 119 yards.

The Colts logged the win when Houston kicker Kris Brown sliced a 42-yarder as time expired that would have forced an overtime period.

Manning was 34 for 50 for 318 yards, one touchdown and one interception. The Colts benefited by a Caldwell challenge shortly before the half. Officials ruled that Texans running back Ryan Moats fumbled out of bounds, but Caldwell challenged and it was ruled that Jerraud Powers had recovered the ball.

INDIANAPOLIS - Patriots coach Bill Belichick's decision to go for it on 4th-and-2 at the Patriots' 28-yard line with a six-point lead sparked weeks of debate.

Colts safety Melvin Bullitt hit the Patriots' Kevin Faulk as he caught Tom Brady's pass and stopped the Pats a yard short. Manning drove the team 29 yards in four plays and hit Wayne with the game-winning pass with 13 seconds left. The Colts came back from a 17-point deficit early in the fourth quarter for the win.

The comeback included two 79-yard fourth-quarter drives, with the longer of the two taking 2:04. Garcon caught a 29-yard touchdown pass on the first drive, and Collie drew a big interference call on the second drive, which culminated in an Addai four-yard run.

Manning was 28 for 44 for 327 yards, four touchdowns and two interceptions. New England quarterback Tom Brady completed 29 of 42 for 375 yards and three scores.

BALTIMORE - The Colts won an NFL-record fourth consecutive game after trailing in the fourth quarter.

Credit the defense in large part for holding the Ravens to five field goals and coming up with a huge interception by Gary Brackett deep in Colts territory in the final three minutes. Special teams then came through when the Ravens' Ed Reed tried to lateral a late punt return, resulting in a fumble recovered by the Colts.

The Colts also benefited from a late-hit personal foul on Haloti Ngata against Garcon that helped the Colts en route to Stover's game-winning field goal.

Manning completed 22 of 31 for 299 yards and one score, but was picked off twice. Garcon had 108 yards receiving and Addai rushed for 74 yards. The Colts defense stuffed Baltimore three times at the 1-yard line and held their run game to 98 yards.

HOUSTON - The Colts trailed 17-0 in the second quarter but kept chipping away until they overtook the Texans on the road to run their record to 11-0.

Manning directed scoring drives of 74, 80 and 89 as the Colts finally took the lead 21-20 on a Manning pass to Clark. Manning finished with 244 yards passing.

The Colts defense essentially sealed the deal when Clint Session picked off a Matt Schaub pass and returned it 27 yards to put the Colts up 28-20. Robert Mathis forced a fumble by Schaub on the next possession, and the Colts made it 35-20 on a Chad Simpson run.

The win clinched the AFC South title, as Indy became only the fourth team to claim a division this early in the season.

INDIANAPOLIS - The Colts tied the New England Patriots for the NFL record of 21 consecutive regular-season wins and extended their record of seven straight seasons with at least 12 wins.

Manning passed for 270 yards, including 136 to Garcon. Addai rushed for 79 yards and two touchdowns. Manning also had a scoring pass to Collie and Stover added two field goals.

The Colts defense forced three turnovers and had two big fourth-down stops. Session, coming off his big interception against the Texans a week earlier, led the team with 13 tackles and forced a fumble.

INDIANAPOLIS - The Colts set an NFL record with their 22nd consecutive regular-season win and also clinched the No.1 AFC playoff seed.

The offense was productive as usual against the Broncos, especially in taking a 21-0 lead on drives of 80, 56 and 71 in the first half. Manning hit Collie with his first touchdown pass and threw two more to Clark.

But it was the Colts defense that made sure the game didn't get away. Indy shut down the Bronocs on 10 of 13 possessions, including two 4th-and-1 run stops by Brackett and Powers, a sack by Brackett, a Tim Jennings interception and a Freeney sack. Broncos receiver Brandon Marshall caught an NFL-record 21 passes (for 200 yards and two touchdowns) in the defense's only real flaw.

The Colts set the record for most wins in a decade (114).

JACKSONVILLE - For the seventh time this season, the Colts came from behind in the fourth quarter for the win.

The game-winning offensive play came on third down in the fourth quarter, with a heavy rush approaching. Manning found Wayne open along the left sideline, he caught the pass and took it 65 yards for the go-ahead touchdown.

The defense came up with two big plays late to seal the deal: Eric Foster sacked David Garrard to force a punt with 2:31 left. When the Colts offense couldn't run out the clock, Jacob Lacey delivered the final big play by picking off an overthrown Garrard pass with 57 seconds left.

The win put the Colts at 14-0 and gave them their 23rd straight regular-season win.

INDIANAPOLIS - Caldwell made a decision that will forever been debated, pulling Manning and other starters with 5:36 left in the third quarter and the Colts holding a 15-10 lead.

By the time the Jets finished pummeling Colts backup quarterback Curtis Painter, the Colts' undefeated record had evaporated and angry Colts fans were booing.

Manning's last drive came after a 106-yard kickoff return touchdown by Brad Smith gave the Jets a 10-9 lead in the third quarter. Manning regained the lead in vintage style, driving the team 81 yards on nine plays, with Brown scoring to put the Colts up 15-10.

The Jets took the lead when Painter was sacked and fumbled, and Jets tackle Marques Douglas recovered for the touchdown. The Jets added a field goal and a 79-yard touchdown run against the Colts backup players.

BUFFALO - Manning and the first-team offense played only three possessions but made the most of their time on the field.

Manning directed a 12-play, 72-yard scoring drive to tie the game 7-7. He also hit Wayne and Clark exactly the number of passes (Wayne 5, Clark 7) needed to get them to an even 100 receptions apiece on the season.

Buffalo's Ryan Fitzpatrick completed 16 of 25 passes for 155 yards and three touchdowns, primarily against the Colts' backup players. Manning was 14 of 18 for 95 yards and was picked off once.

The Colts finished the regular season 14-2.

INDIANAPOLIS - Manning shook off any signs of rust with two big touchdown passes in the last two minutes of the half to forge a 17-3 lead and control of the game.

Manning directed a 14-play, 75-yard drive over eight minutes, capped by a 10-yard scoring pass to Collie to give the Colts a 10-3 lead. Regaining possession with 1:26 left, Manning drove the Colts 64 yards for the score on a three-yard pass to Wayne. The Colts got a big third-quarter play by Garcon, who chased down Ed Reed after Reed intercepted the ball, and forced a fumble, which Clark recovered.

The Colts defense held the Ravens to 87 yards rushing, Brackett recorded a big sack, and Antoine Bethea and Powers both intercepted Joe Flacco.

INDIANAPOLIS - What would the Colts season be without another comeback win?

The Jets took at 17-6 lead on big plays and two TD passes by quarterback Mark Sanchez, but Manning and the offense provided the spark needed to come from behind and advance to their second Super Bowl in four seasons.

Manning's first drive consisted of three passes to Collie in a span of 58 seconds and covered 80 yards right before halftime. The highlight of that drive was a perfectly thrown 46-yard to Collie between two Jets defenders. Manning hit Garcon four times, including a fade-route touchdown score, to put the Colts up 20-17 in the third quarter.

The Colts held the Jets scoreless in the second and limited their running game to 86 yards.